

Additionally, scopolamine has also proven to be clinically effective for palliatively treating more obscure forms of motion sickness, such as the poorly understood Sopite Syndrome which can change mood, cognitive functions and a sufferer's overall sense of well-being in a more profound way than the stereotypical symptoms of motion sickness like nausea and vertigo. Such drugs taken to relieve typical symptoms of motion sickness (including nausea, dizziness, etc.) contain compounds that may exacerbate drowsiness, especially if not dosed modestly or within their therapeutic windows.
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In these contexts, its mind-altering effects have been utilized for recreational, criminal and occult purposes.

Scopolamine is also the main active component produced by certain plants of the nightshade family, which historically have been used as psychoactive drugs (known as deliriants) due to their antimuscarinic-induced hallucinogenic effects in higher doses. Scopolamine was first written about in 1881 and started to be used for anesthesia around 1900. Scopolamine is in the antimuscarinic family of drugs and works by blocking some of the effects of acetylcholine within the nervous system. Its duration of action for oral administration is less well-studied, and may often be confounded by other factors but based on preliminary or circumstantial observations it can be deduced as lasting around 8 hours, but possibly even up to 18 hours or longer depending on the dosage. It may also be used orally, and as a transdermal patch since it has been long known to have transdermal bioavailability. When used by injection, effects begin after about 20 minutes and last for up to 8 hours. It is also sometimes used as an antisialagogue before surgical anaesthesia to decrease salivation (secretion of saliva). Scopolamine, also known as hyoscine, or Devil's Breath, is a natural or synthetically produced tropane alkaloid and anticholinergic drug that is used as a medication to treat motion sickness and postoperative nausea and vomiting.
